The programme of the HEC21 meeting is now available (please note: The conference/lectures will begin at 3 pm on Thursday, Sep 20th!). We are greatly honoured that this year’s HEC lecture entitled “A personal history of structural virology from haemoglobin to Zika virus” will be delivered by Michael G. Rossmann.
HEC21 Programme: Thursday 20.09.2018
HEC21 Programme: Friday 21.09.2018
| Session III | Protein and RNA modifying enzymes (Chair: Mariusz Jaskolski) | |
| 08:30 - 08:40 | James Gordon Molecular Dimensions | Improving crystals by collaboration - Innovation from Molecular Dimensions |
| 08:40 - 09:00 | Sandra Riemer* Steegborn | Molecular studies on Sirt1 regulation by its binding partner AROS |
| 09:00 - 09:20 | Saša Petrović* Heinemann | Structural basis of ASPL-mediated regulation of p97 methylation by METTL21D |
| 09:20 - 09:40 | Deepshikha Malik* Nowotny | Structure and mechanism of mitochondrial RNAse Rexo2 |
| 09:40 - 10:00 | Florian Hamann* Ficner | Crystallographic insights into the translocation mechanism of DEAH-box ATPases |
| 10:00 - 10:20 | Marta Pabis Glatt | Structural and functional characterization of Uba4, an essential enzyme in the tRNA thiolation pathway |
| 10:20 - 10:30 | Stefan Kolek Douglas Instruments | New strategies to improve productivity - rMMS microseeding for crystallization and DLS for cryoEM |
| 10:30 - 11:00 | Coffee break | |
| Session IV | Challenging structure determinations (Chair: Manfred S. Weiss) | |
| 11:00 - 11:10 | Alevtyna Yakushevska ThermoFischer | Thermo Fisher Scientific support in engaging in Cryo-EM SPA |
| 11:10 - 11:30 | Joanna Smietanska* Jaskolski | The landscape of Hyp-1 superstructure modulation |
| 11:30 - 11:50 | Stefanie Hanke* Sträter | Structural studies on inhibitor binding to human kallikrein 7 |
| 11:50 - 12:10 | Francesca De Bortoli* Wahl | Structural and functional characterization of the spliceosomal protein Prpf39 |
| 12:10 - 12:30 | Antonia Vogel* Clausen | Keeping muscle proteins in shape - Delineating the substrate-targeting mechanism of UCS proteins that function as myosin-specific quality-control factors |
| 12:30 - 12:50 | Tamara Sijacki Djinovic-Carugo | Behind the muscle function: Structure of F-actin–α-ctinin-2 complex |
| 12:50 - 13:00 | Emanuel Katzmann JEOL | Advances in cryo electron microscopy instrumentation |
| 13:00 - 14:00 | Lunch | |
| 14:00 - 18:00 | HEC21 photo & social event | |
| Session V | Designed proteins & RNAs (Chair: Wulf Blankenfeldt) | |
| 18:00 - 18:20 | Florian Grau* Muller | Structural insights into a synthetic TetR protein – RNA aptamer switch |
| 18:20 - 18:40 | Lucia Motlova* Bařinka | Structural basis of prostate-specific membrane antigen recognition by the A9g RNA aptamer |
| 18:40 - 19:00 | Jiří Zahradník* Schneider | High resolution structure of a PROSS designed variant of human cytokine |
| 19:00 - 19:20 | Rezan Amjadi* Scheffzek | Per Aspera ad Astra (but without Astra) - trying to define hopefully crystallizing constructs in a protein of locally complex structure |
| 19:20 - 19:40 | Alaa Shaikhqasem* Ficner | Cancer treatment by inhibition of nuclear export – crystal structure of a human CRM1-inhibitor complex |
| 19:40 - 19:50 | Mark Benson Rigaku | What's old is new: The HyPix-Arc 150° |
| 19:50 - 20:00 | Special announcement | |
| 20:00 - late | Dinner & dance |
HEC21 Programme: Saturday 22.09.2018
| Session VI | Membrane and membrane-associated proteins (Chair: Yves Muller) | |
| 08:30 - 08:40 | Vernon Smith Bruker | Low-maintenance home-lab systems for biological crystallography - Performance without the pain |
| 08:40 - 09:00 | Marie Witt* Daumke | Structure-function studies on FIP200 reveal mechanistic insights into selective autophagy |
| 09:00 - 09:20 | Sonja Minniberger* Plested | Structural studies of mutants of the NaK channel |
| 09:20 - 09:40 | Dennis Kwiatkowski* Scheerer | New insights into the structure of light-activated rhodopsin and G protein specificity |
| 09:40 - 10:00 | Nicolas Heyder* Scheerer | Structural characterization of GPCRs in appetite control: melanocortin-4 receptor (MC4R) & ghrelin receptor (GHSR) |
| 10:00 - 10:20 | Mandy Geisler* Sträter | Calcium-sensing receptor – A multifaceted sensor in the human body |
| 10:20 - 11:00 | Coffee break and check out | |
| Session VII | Synchrotron facilities for HEC (and others…) (Chair: Klaus Scheffzek) | |
| 11:00 - 11:20 | Jan Wollenhaupt Weiss | Crystallographic Fragment Screening at HZB |
| 11:20 - 11:40 | Anastasya Shilova Müller | Development of serial millisecond crystallography at BioMAX beamline |
| 11:40 - 12:00 | Martin Gerlach Weiss | Facilities for macromolecular crystallography at the HZB |
| 12:00 - 12:10 | Announcement of HEC22 | |
| 12:10 | Milton T. Stubbs | HEC prize award and closing remarks |
| 12:20 - 13:30 | Lunch and departure |