Scientific Programme

The programme of the HEC21 meeting is now available (please note: The conference/lectures will begin at 3 pm on Thursday, Sep 20th!). We are greatly honoured that this year’s HEC lecture entitled “A personal history of structural virology from haemoglobin to Zika virus” will be delivered by Michael G. Rossmann.

Programme Download (PDF)

HEC21 Programme: Thursday 20.09.2018

12:00 - 15:00Registration
15:00 - 15:10Milton T. StubbsOpening remarks
15:10 - 15:20New HEC groupsMichael Lammers
Miriam Linnert
Session IEnzyme specificity and mechanisms (Chair: Norbert Sträter)
15:20 - 15:40Honorata Czapińska
Modification dependent endonucleases
15:40 - 16:00Petra Havlickova*
Kutá Smatanová
Crystallographic studies of histidinol-phosphate phosphatase Tt82 from Thermococcus onnurineus
16:00 - 16:20Jędrzej Rum*
Active site adaptability of cold-adapted PsyArAT to bind different sized substrates
16:20 - 16:40Leona Švecová*
So, what does the enzyme do? Structural data-based identification of substrate specificity
16:40 - 17:00Archna Archna
Elucidating the mechanism of the chorismate dehydratase MqnA from Streptomyces coelicolor: searching for ligand-free crystals
17:00 - 17:30Coffee break
Session IIProteins from pathogens (Chair: Pavlina Řezáčová)
17:30 - 17:40Christin Reuter
Jena Bioscience
Crystal growth to data collection made easy
17:40 - 18:00Maurice Diwo*
Phospholipases from Legionella pneumophila
18:00 - 18:20Thomas Klünemann*
C-type cytochromes and eight-bladed β-propellers during nitrite reduction and heme d1 biosynthesis
18:20 - 18:40Sofia Banchenko
X-ray and cryo-EM structural studies of viral hijacking of the Cullin4-RING ligase ubiquitin-proteasome pathway
18:40 - 19:00Johannes Schweininger*
Of rats and men: Insight into homologous cytomegalovirus IE1 structures
19:00 - 20:00Dinner
HEC lecture 2018Chair: Milton T. Stubbs
20:00 - 21:00Michael G. Rossmann
Purdue University
A personal history of structural virology from haemoglobin to Zika virus
21:00 - lateDiscussion & bar

HEC21 Programme: Friday 21.09.2018

Session IIIProtein and RNA modifying enzymes (Chair: Mariusz Jaskolski)
08:30 - 08:40James Gordon
Molecular Dimensions
Improving crystals by collaboration - Innovation from Molecular Dimensions
08:40 - 09:00Sandra Riemer*
Molecular studies on Sirt1 regulation by its binding partner AROS
09:00 - 09:20Saša Petrović*
Structural basis of ASPL-mediated regulation of p97 methylation by METTL21D
09:20 - 09:40Deepshikha Malik*
Structure and mechanism of mitochondrial RNAse Rexo2
09:40 - 10:00Florian Hamann*
Crystallographic insights into the translocation mechanism of DEAH-box ATPases
10:00 - 10:20Marta Pabis
Structural and functional characterization of Uba4, an essential enzyme in the tRNA thiolation pathway
10:20 - 10:30Stefan Kolek
Douglas Instruments
New strategies to improve productivity - rMMS microseeding for crystallization and DLS for cryoEM
10:30 - 11:00Coffee break
Session IVChallenging structure determinations (Chair: Manfred S. Weiss)
11:00 - 11:10Alevtyna Yakushevska
Thermo Fisher Scientific support in engaging in Cryo-EM SPA
11:10 - 11:30Joanna Smietanska*
The landscape of Hyp-1 superstructure modulation
11:30 - 11:50Stefanie Hanke*
Structural studies on inhibitor binding to human kallikrein 7
11:50 - 12:10Francesca De Bortoli*
Structural and functional characterization of the spliceosomal protein Prpf39
12:10 - 12:30Antonia Vogel*
Keeping muscle proteins in shape - Delineating the substrate-targeting mechanism of UCS proteins that function as myosin-specific quality-control factors
12:30 - 12:50Tamara Sijacki
Behind the muscle function: Structure of F-actin–α-ctinin-2 complex
12:50 - 13:00Emanuel Katzmann
Advances in cryo electron microscopy instrumentation
13:00 - 14:00Lunch
14:00 - 18:00HEC21 photo & social event
Session VDesigned proteins & RNAs (Chair: Wulf Blankenfeldt)
18:00 - 18:20Florian Grau*
Structural insights into a synthetic TetR protein – RNA aptamer switch
18:20 - 18:40Lucia Motlova*
Structural basis of prostate-specific membrane antigen recognition by the A9g RNA aptamer
18:40 - 19:00Jiří Zahradník*
High resolution structure of a PROSS designed variant of human cytokine
19:00 - 19:20Rezan Amjadi*
Per Aspera ad Astra (but without Astra) - trying to define hopefully crystallizing constructs in a protein of locally complex structure
19:20 - 19:40Alaa Shaikhqasem*
Cancer treatment by inhibition of nuclear export – crystal structure of a human CRM1-inhibitor complex
19:40 - 19:50Mark Benson
What's old is new: The HyPix-Arc 150°
19:50 - 20:00Special announcement
20:00 - lateDinner & dance

HEC21 Programme: Saturday 22.09.2018

Session VIMembrane and membrane-associated proteins (Chair: Yves Muller)
08:30 - 08:40Vernon Smith
Low-maintenance home-lab systems for biological crystallography - Performance without the pain
08:40 - 09:00Marie Witt*
Structure-function studies on FIP200 reveal mechanistic insights into selective autophagy
09:00 - 09:20Sonja Minniberger*
Structural studies of mutants of the NaK channel
09:20 - 09:40Dennis Kwiatkowski*
New insights into the structure of light-activated rhodopsin and G protein specificity
09:40 - 10:00Nicolas Heyder*
Structural characterization of GPCRs in appetite control: melanocortin-4 receptor (MC4R) & ghrelin receptor (GHSR)
10:00 - 10:20Mandy Geisler*
Calcium-sensing receptor – A multifaceted sensor in the human body
10:20 - 11:00Coffee break and check out
Session VIISynchrotron facilities for HEC (and others…) (Chair: Klaus Scheffzek)
11:00 - 11:20Jan Wollenhaupt
Crystallographic Fragment Screening at HZB
11:20 - 11:40Anastasya Shilova
Development of serial millisecond crystallography at BioMAX beamline
11:40 - 12:00Martin Gerlach
Facilities for macromolecular crystallography at the HZB
12:00 - 12:10Announcement of HEC22
12:10Milton T. StubbsHEC prize award and closing remarks
12:20 - 13:30Lunch and departure